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目的:观察顺尔宁联合喘可治佐治小儿毛细支气管炎的临床疗效及其安全性。方法:选取2010年9月～2012年3月在我院儿科住院的70例毛细支气管炎患儿作为观察对象,按入院先后顺序随机分为治疗组和对照组,每组35例。两组均常规给予抗感染、解痉平喘、吸氧、镇静等综合治疗,治疗组在常规治疗的基础上加顺尔宁(孟鲁司特钠咀嚼片)口服,每天4 mg,每晚1次,以及喘可治注射液口服,每次半支,2次/日。治疗7天后观察和比较两组患儿的临床疗效,并对所有病例门诊随访3个月,观察各组患儿在此期间喘息再次发作的情况。结果:治疗7天后,治疗组的总有效率为97.1%,对照组的有效率为80.0%,两组间有显著性差异(X2=7.83,P<0.05)。治疗组症状体征平均持续时间均较对照组明显缩短,差异有统计学意义(P<0.05)。随访3个月内治疗组喘息反复发作的平均次数显著低于对照组,差异有统计学意义(P<0.05)。两组均未见严重不良反应。结论:顺尔宁联合喘可治佐治毛细支气管炎临床疗效显著,并能缩短住院时间,由于顺尔宁可控制毛细支气管炎后的气道慢性炎症,喘可治注射液可增强呼吸道抵抗能力、减少呼吸道反复感染,对毛细支气管炎后喘息的反复发作有预防作用。
Objective: To observe the clinical efficacy and safety of combination of Salbutamol and chuankezhi in treating pediatric bronchiolitis. Methods: Seventy patients with bronchiolitis who were hospitalized in pediatrics of our hospital from September 2010 to March 2012 were selected as observation objects, and randomly divided into treatment group and control group according to admission order, with 35 cases in each group. Both groups were routinely given anti-infection, antispasmodic and antiasthmatic, oxygen, sedation and other comprehensive treatment, the treatment group on the basis of conventional treatment plus sialnin (montelukast sodium chewable tablets) orally, 4 mg daily, 1 night , And Chuankezhi injection orally, each half-branch, 2 times / day. After 7 days of treatment, the clinical curative effect of both groups was observed and compared. All the cases were followed up for 3 months and the resuscitation of wheezing in each group was observed. Results: After 7 days of treatment, the total effective rate was 97.1% in the treatment group and 80.0% in the control group. There was a significant difference between the two groups (χ2 = 7.83, P <0.05). The mean duration of symptoms and signs in the treatment group was significantly shorter than that in the control group, with statistical significance (P <0.05). The mean number of repeated episodes of wheezing in the treatment group within 3 months of follow-up was significantly lower than that of the control group (P <0.05). No serious adverse reactions were seen in both groups. CONCLUSIONS: SFD combined with Chuankezhi has significant clinical curative effect on bronchiolitis and can shorten the length of hospital stay. As Shundening can control airway chronic inflammation after bronchiolitis, Chuankezhi injection can enhance respiratory resistance and reduce Repeated respiratory infections, repeated episodes of wheezing after bronchitis have a preventive effect.