目的:了解医院分离鲍曼不动杆菌(Ab)的药敏变化,为临床经验性治疗提供参考。方法:回顾性分析山东省立医院2011~2015年Ab药敏变化趋势及不同部位菌株药敏情况。结果:2011~2015年共分离非重复Ab 1 355株,主要分布于痰、皮肤软组织、导管、尿、脑脊液等5个不同部位,分离自非ICU住院患者的菌株占67.23%;亚胺培南耐药株占53.50%,所有菌株对多黏菌素及替加环素的敏感率均>90%,其他药物敏感率均<70%。2012年比2011年、2013年比2012年菌株对14种抗菌药物中的11种敏感性显著升高(P<0.05);但2014年比2013年药敏变化不明显,2015年比2014年对各药物的敏感性显著下降(P<0.05);不同部位Ab对抗菌药物的敏感性略有差异;除多黏菌素及替加环素,碳青霉烯耐药鲍曼不动杆菌对各种药物敏感率均<30%。结论:Ab可能存在传播,应加强院内感染控制;Ab大多为多重耐药菌,临床治疗可选药物有限,应监测药敏变化或根据药敏结果合理选择抗菌药物。 Objective: To understand the change of drug sensitivity of Acinetobacter baumannii (Ab) isolated in hospital and provide reference for clinical experience treatment. Methods: A retrospective analysis of Shandong Provincial Hospital from 2011 to 2015 Ab drug susceptibility trends and different parts of the strain susceptibility. Results: A total of 1 355 non-repetitive Ab 1 355 strains were isolated from 2011 to 2015. They were mainly distributed in 5 different sites such as sputum, skin and soft tissue, catheter, urine and cerebrospinal fluid. The isolates from non-ICU inpatients accounted for 67.23% The resistant strains accounted for 53.50%. All strains were sensitive to both polymyxin and tigecycline, with the sensitivity rates of> 90% and other drugs <70%. The sensitivity of strains to 11 of the 14 antimicrobial agents was significantly higher (P <0.05) than that of 2011, 2013 and 2012 compared with 2012; however, the sensitivity to antibiotics was not significantly different from that of 2013 to 2013, and from 2015 to 2014 The sensitivity of each drug was significantly decreased (P <0.05); different parts of the sensitivity of antibacterial Ab slightly different; in addition to polymyxin and tigecycline, carbapenem-resistant Acinetobacter baumannii each The sensitivity of the drugs were <30%. Conclusion: Ab may be transmitted and nosocomial infection should be controlled. Ab, mostly multi-drug resistant, has limited clinical options. Drug susceptibility changes should be monitored or antimicrobial agents should be selected appropriately based on susceptibility results.