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为了解强的松对心肺肝脾肾影响的病理改变,应用正常Wistar大白鼠28只,分实验组及对照组各14只。实验组给予相当于人2mg/kg.d等效剂量的强的松片剂溶入当日饮水中,对照组饮自来水,共10周,之后解剖光镜见对照组心肺肝脾肾及实验组心肺均无异常。实验组肝肾轻度充血,脾充血明显,且见较多舍铁血黄素沉着,以红髓边缘明显。证实常规剂量的强的松对肝脾肾也有一定不良影响,应用激素时要注意及时调整剂量和给药方式与时间,尽量减少副作用。
In order to understand the pathological changes of prednisone on heart, lung, spleen and kidney, 28 normal Wistar rats were divided into experimental group and control group with 14 rats in each group. The experimental group was given equivalent dosage of 2mg / kg.d prednisone tablets into the drinking water on the day, the control group drinking tap water for 10 weeks, then dissected light microscope control group of heart and lung, liver, spleen and kidney and experimental group of lung No abnormalities. Experimental group mild hyperemia liver and kidney, spleen congestion was obvious, and see more hemosiderin deposition, the edge of the red pulp obvious. Confirmed that the conventional dose of prednisone on liver and spleen and kidney also have some adverse effects, the application of hormones should pay attention to timely adjustment of dose and mode of administration and time to minimize side effects.