以基因组DNA和组蛋白的共价修饰为主要标志的表观遗传调控研究已成为生命科学前沿快速发展的热点领域,其中组蛋白甲基化对于基因的转录表达,细胞增殖分化等起着至关重要的调控作用,相关甲基化酶基因的突变或异常会导致多种遗传疾病和癌症发生.中国科学院上海生命科学研究院生化与细胞研究所国家 The study of epigenetic regulation with covalent modification of genomic DNA and histone as the major marker has become a hot area in the frontier of life sciences, in which histone methylation plays a crucial role in gene transcription and cell proliferation and differentiation Important regulatory role, related to mutations or abnormal methylase gene can lead to a variety of genetic diseases and cancer. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Institute of Biochemistry and Cell Biology