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目的:采用乙肝系列中成药(乙肝清热解毒颗粒、乙肝益气解郁颗粒、乙肝养阴活血颗粒)探讨中医清热解毒法、益气解郁法、养阴活血法单独使用及联合应用对免疫性肝纤维化模型大鼠肝功能和血清肝纤维化四项指标的影响。方法:用猪血清腹腔注射诱导免疫性肝纤维化模型,成模后再用乙肝系列中成药进行干预治疗,用全自动生化分析仪测定肝功能,用放射免疫分析法测定血清肝纤维化四项指标。结果:猪血清诱导的肝纤维化大鼠血清中ALT、AST、HA、LN、IV-C和PC-Ⅲ含量均明显升高(P<0.05,P<0.01),经乙肝系列中成药治疗后,上述指标明显降低(P<0.05,P<0.01),且合方效果优于单方,清热解毒法和益气解郁法的联合应用能更好的改善肝功能,清热解毒法和养阴活血法的联合应用能更好的改善肝纤维化四项指标。结论:中医清热解毒法、益气解郁法、养阴活血法对免疫性肝纤维化有一定的防治作用,能降低肝纤维化程度,同时可减轻肝细胞损伤,改善肝功能。
OBJECTIVE: To investigate the effect of clearing away heat and toxic materials, clearing away qi and dissipating stagnation, promoting yin and activating blood circulation, and the combination of traditional Chinese medicine (TCM) on immune liver fibrosis Effects of Four Indexes of Liver Function and Serum Hepatic Fibrosis in Model Rats. Methods: The model of autoimmune liver fibrosis induced by intraperitoneal injection of porcine serum was established. After the model was established, the model group was treated with proprietary Chinese medicine of hepatitis B series. The liver function was measured by automatic biochemical analyzer and the serum level of liver fibrosis was measured by radioimmunoassay index. Results: The contents of ALT, AST, HA, LN, IV-C and PC-Ⅲ in serum of rats with liver fibrosis induced by swine serum were significantly increased (P <0.05, P <0.01) (P <0.05, P <0.01), and the combination effect is superior to unilateral, the combination of heat-clearing and detoxifying method and Qi-qi stagnation method can better improve liver function, clearing away heat and toxic materials and the method of nourishing Yin and promoting blood circulation Joint application can better improve the four indicators of liver fibrosis. Conclusion: The Qingrejiedu method, Qi-qi-qi-yu method and Yangyinhuoxue method have some preventive and therapeutic effects on autoimmune liver fibrosis, can reduce the degree of liver fibrosis, reduce the damage of liver cells and improve the liver function.