咬合紊乱与颞下颌关节紊乱病的关系一直是现代口腔医学研究的热点问题之一。笔者课题组通过建立咬合紊乱动物模型,观察到颞下颌关节髁突的异常改建甚至退行性变。咬合紊乱产生的异常生物力可以影响髁突软骨细胞的增殖、分化和凋亡,细胞外基质降解和钙化,以及软骨下骨吸收等一系列变化,是髁突退行性改变的重要机制。文章就实验性咬合紊乱对髁突的影响进行综述。 Occlusal disorders and the relationship between temporomandibular disorders has been one of the hot issues in modern stomatology. The author task group through the establishment of bite disorder animal model observed abnormal changes in the temporomandibular joint condyles and even degenerative changes. Abnormal biomechanics produced by occlusion disorders can affect a series of changes of condylar chondrocytes proliferation, differentiation and apoptosis, extracellular matrix degradation and calcification, and subchondral bone resorption, which are important mechanisms of condylar degeneration. The article reviewed the effects of experimental occlusal disorders on condyles.