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目的 观察Ａ型肉毒毒素对原发性眼睑痉挛和Ｍｅｉｇｅ 综合征的治疗效果。方法 Ａ型肉毒毒素， 在肌电图仪的引导下对眼轮匝肌进行多点局部注射（每点２．５～５Ｕ） 治疗原发性眼睑痉挛２４ 例及Ｍｅｉｇｅ综合征１０例。结果 ４～５ 天出现症状缓解， １ 个星期症状明显缓解， ２ 个星期症状缓解最明显。有效率１００％ ， 原发性眼睑痉挛有效作用时间为１０～２４ 周， 平均为１５．８ 周。Ｍｅｉｇｅ 综合征平均有效作用时间为１１．７ 周。结论 Ａ型肉毒毒素局部注射是治疗眼睑痉挛和Ｍｅｉｇｅ 综合征的一种安全、有效、简便方法。
Objective To observe the therapeutic effect of botulinum toxin type A on primary blepharospasm and Meige syndrome. Methods A botulinum toxin type A was used to treat 24 cases of primary blepharospasm and 10 cases of Meige syndrome under the guidance of EMG. Results 4 to 5 days to relieve symptoms, symptoms were significantly alleviated in 1 week, 2 weeks to alleviate the most obvious symptoms. Effective rate of 100%, the effective effect of primary blepharospasm for 10 to 24 weeks, with an average of 15.8 weeks. The average effective duration of Meige syndrome was 11.7 weeks. Conclusion Botulinum toxin type A injection is a safe, effective and convenient method for treating blepharospasm and Meige syndrome.