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有报告提出,当多巴胺(DA)与生物受体部位点作用时,它的优势构象与DA完全伸展的反式相似。在此构象中,儿茶酚环和氨基在同一平面内并在相距最远的位置上。生物上有意义的构象,其间位羟基转向氨基(如Ⅰ),这种排列称为α-旋转异构体(α-rotamer);间位羟基背离氨基的称为β-旋转异构体。儿茶酚环和乙胺系统两个平面间角近似180°,接近共平面,这是导致多巴胺能活性的重要结构特点。最近报道苯并氮杂(艹卓)衍生物(Ⅱ)具有明显调节
It has been reported that when dopamine (DA) interacts with the site of the biological receptor, its dominant conformation is similar to that of DA fully extended trans. In this conformation, the catechin ring and the amino group are in the same plane and at the farthest distant position. The biologically interesting conformation, in which the hydroxyl to amino (such as Ⅰ), this arrangement is called α-rotamer (α-rotamer); meta-hydroxyl away from the amino group is called β-rotamer. Catechol ring and ethylamine system, the angle between the two planes is approximately 180 °, near coplanar, which is an important structural feature leading to dopaminergic activity. Recently reported benzazepine (艹 Zhuo) derivatives (Ⅱ) has obvious regulation