乙炔气通入含水10%的氢氧化钾粉末直接反应,可制得含10～15%炔钾的混合物,它可作为有用的炔化剂,并发现α、β-不饱和甾体二酮,在无氧存在的条件下,以丙酮为触媒,能区域选择性地发生炔化,如化合物1a 生成高收率的17α-炔基物2a。不同的反应温度能改变立体选择性,如化合物3和5在低温条件下分别生成收率较高的2α,17α-双炔基物4a 和6a。该法亦适用于其他甾体化合物。 The acetylene gas is passed directly into a 10% aqueous potassium hydroxide powder to produce a mixture containing 10-15% of potassium alkyne, which can be used as a useful alkynylation agent, and found that α, β-unsaturated steroidal diketones, In the absence of oxygen in the presence of acetone as a catalyst, the region can be selectively alkyne, such as compound 1a to generate high yield 17α-alkynyl 2a. Different reaction temperatures can change the stereoselectivity. For example, compounds 3 and 5 produce higher yields of 2α, 17α-diynyne 4a and 6a, respectively, at low temperature. The law also applies to other steroidal compounds.