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目的探讨脑利钠肽(brain natriuretic peptide,BNP)与超声心动图在川崎病急性期及恢复期诊断中的临床意义。方法选取川崎病患儿35例为病例组,以发热、皮疹为主诉的肺炎支原体或病毒感染的48例患儿为对照组,测其急性期与恢复期脑利钠肽及左、右冠状动脉内径值,并做相关分析。结果川崎病患儿急性期脑利钠肽值明显高于恢复期,且差异有统计学意义;川崎病患儿恢复期冠状动脉内径值明显高于急性期,且差异有统计学意义。结论应用超声心动图检测冠状动脉扩张是在恢复期诊断川崎病的重要手段,而脑利钠肽可作为急性期诊断川崎病的生化指标之一。
Objective To investigate the clinical significance of brain natriuretic peptide (BNP) and echocardiography in the diagnosis of acute and convalescent Kawasaki disease. Methods 35 children with Kawasaki disease were selected as the case group. Forty-eight children with Mycoplasma pneumoniae or viral infection, which were mainly fever and rash, were selected as the control group. Brain natriuretic peptide and left and right coronary arteries were measured during acute and convalescent phase Diameter value, and do related analysis. Results The acute brain natriuretic peptide in children with Kawasaki disease was significantly higher than that in recovery stage, and the difference was statistically significant. The diameter of coronary artery in Kawasaki disease recovery group was significantly higher than that in acute phase, and the difference was statistically significant. Conclusions The application of echocardiography to detect coronary artery dilatation is an important means to diagnose Kawasaki disease in convalescence. Brain natriuretic peptide can be used as one of the biochemical markers to diagnose Kawasaki disease in acute phase.