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目的：研究慢性肾功能不全（ＣＲＦ）患者血清及尿一氧化氮（ＮＯ）含量及其意义。方法：测定３４例ＣＲＦ患者血清及尿ＮＯ含量，并与其血压、血尿素（ＢＵＮ）及血肌酐（ＳＣｒ）作了相关性分析。结果：ＣＲＦ患者血清及尿ＮＯ含量分别是（９．２９±５．５２ｍｇ／ｍＬ和（９．６０±２．８３）ｍｇ／ｍＬ，低于健康人，有统计学显著差异（Ｐ＜０．０５）；血清及尿ＮＯ与患者的血压、ＢＵＮ及ＳＣｒ均无相关性。结论：ＣＲＦ患者血清及尿ＮＯ明显降低。
Objective: To study the serum and urinary nitric oxide (NO) levels in patients with chronic renal failure (CRF) and its significance. Methods: Serum and urinary NO levels were measured in 34 patients with CRF and their correlations were analyzed with their blood pressure, blood urea nitrogen (BUN) and serum creatinine (SCr). Results: Serum and urinary NO levels in patients with CRF were (9.29 ± 5.52mg / mL and 9.60 ± 2.83) mg / mL, respectively, which were significantly lower than those in healthy people (P <0.05). There was no correlation between serum and urinary NO and blood pressure, BUN and SCr.Conclusion: Serum and urinary NO significantly decreased in patients with CRF.