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多发性内分泌腺病(Multiple endocrineadenopathy,MEA)属遗传性一组内分泌腺机能亢进的综合征,分三类:MEA-I、MEA-II和MEA-IIB。MEA-I即Wermer综合征,涉及甲状旁腺机能亢进(HPT)、胰岛细胞瘤、胃泌素瘤或胰岛素瘤及垂体腺瘤。MEA-II即Sipple综合征,包括HPT、甲状腺髓样癌(MCT)和嗜铬细胞瘤(PCC)。MEA-IIB是由MCT和PCC而无HPT构成的综合征。MEA-I:Wermer综合征MEA-I中,不同腺体罹病率分别是:甲状旁腺机能亢进最常见,90％病人有典型的主细胞增生;65％有垂体腺瘤,多数无功能;50％有
Multiple endocrine gland disease (MEA) is a hereditary group of endocrine hyperthyroidism syndromes, divided into three categories: MEA-I, MEA-II and MEA-IIB. MEA-I is Wermer syndrome, which involves hyperparathyroidism (HPT), islet cell tumor, gastrinoma or insulinoma, and pituitary adenoma. MEA-II is Sipple syndrome, including HPT, medullary thyroid carcinoma (MCT) and pheochromocytoma (PCC). MEA-IIB is a syndrome consisting of MCT and PCC without HPT. MEA-I: Wermer syndrome MEA-I, the different glandular morbidity rates were: hyperparathyroidism is the most common, 90% of patients have typical proliferation of primary cells; 65% have pituitary adenomas, most of them have no function; 50 %Have