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讨论 恶性黑色素瘤多发生于头颈部皮肤。Moore报告1546例中头颈部占27.6％,耳鼻咽喉部位占1.7～2.7％。1869年Luck首次报告了鼻腔恶性黑色素瘤及手术治疗。Grace报告48例中18例有鼻息肉摘除史,本组15例中则有7例。Lerner等认为脑垂体中叶内有一种黑色素生成激素。因此,儿童由于内分泌系统发育不健全而很少发生本病,相反,妇女在怀孕期则易患此病。本组8例女性病人6例在40岁以上,
Discussion Malignant melanoma occurs in the skin of the head and neck. Moore reported that 1546 cases accounted for 27.6% of the head and neck, otolaryngology accounted for 1.7 to 2.7%. In 1869 Luck first reported nasal malignant melanoma and surgical treatment. Grace reported that 18 of 48 patients had a history of nasal polyps removal, and 7 out of 15 patients in this group. Lerner et al. believe that there is a melanin production hormone in the middle pituitary gland. Therefore, children rarely develop the disease because of the imperfect development of the endocrine system. On the contrary, women are susceptible to the disease during pregnancy. Six cases of female patients in this group were over 40 years old.