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目的:探讨左乙拉西坦(LEV)添加疗法治疗青年难治性部分性癫痫的疗效,及对患者认知功能的影响。方法:62例难治性部分性癫痫青年患者随机分为A组(n=32)和B组(n=30)。B组给予苯巴比妥片+卡马西平片治疗,A组在B组基础上加用左乙拉西坦片。均持续给药6个月后,比较两组临床疗效、患者认知功能及生活质量差异,以及药品不良反应发生情况。结果:治疗后,A组治疗后12周与24周的总有效率均明显高于B组(P<0.05);A组患者Mo CA评估及SF-36评估评分也均优于B组(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对患难治性部分性癫痫的青年患者给予常规药物联合LEV疗法,疗效确切,对其认知功能的提升具有积极意义,值得临床推广。
Objective: To investigate the efficacy of levetiracetam (LEV) in the treatment of young patients with refractory partial epilepsy and its effect on cognitive function. Methods: Sixty-two young patients with refractory partial epilepsy were randomly divided into group A (n = 32) and group B (n = 30). Group B was treated with phenobarbital + carbamazepine, group A was added with levetiracetam on the basis of group B. After six months of sustained administration, the clinical efficacy, differences in cognitive function and quality of life, and incidence of adverse drug reactions were compared between the two groups. Results: After treatment, the total effective rate of group A at 12 weeks and 24 weeks was significantly higher than that of group B (P <0.05). The scores of Mo CA and SF-36 in group A were also better than those in group B <0.05). There was no significant difference between the two groups in the incidence of adverse drug reactions (P> 0.05). Conclusion: The combination of conventional drug and LEV therapy for young patients with refractory partial epilepsy has definite curative effect and has positive significance to the promotion of cognitive function. It is worthy of clinical promotion.