粘液素分子是一种主要由杯状细胞分泌的大分子糖蛋白 ,其编码基因位于多条染色体上的不同区带 ,分泌产物广泛分布于气道、胃肠道及生殖道 ,主要担任保护和润滑气道 ,吸附吸入的分子、碎屑、衰老细胞及细胞产物的运输和清除功能。在病理条件下 ,多种因素可导致其分泌增高 ,使管腔堵塞 ,可诱发哮喘。粘液素高分泌的调节研究发现 ,刺激性气体、炎症介质、蛋白酶、活性氧、神经肽等多种因素导致粘液素基因表达增高 ,其表达调控涉及多个信号转导级联反应 The mucin molecule is a macrophage glycoprotein secreted mainly by goblet cells. The mucin molecule encodes different bands on multiple chromosomes. The secreted products are widely distributed in the airway, gastrointestinal tract and genital tract, and mainly serve as a protective and Lubricate airways, adsorb inhaled molecules, debris, senescent cells and transport and clearance of cellular products. Under pathological conditions, a variety of factors can lead to increased secretion, clogging the lumen, can induce asthma. Mucosal hypersecretion regulation study found that irritant gas, inflammatory mediators, proteases, reactive oxygen species, neuropeptides and other factors lead to increased mucin expression, the regulation of its expression involves multiple signal transduction cascades