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作者以体外试验对如何加强肿瘤细胞免疫原性进行了探讨,将肿瘤患者的淋巴细胞与实体瘤细胞进行体外培养,以H~3——胸腺嘧啶掺入到淋巴细胞的核蛋白的量作为淋巴细胞对肿瘤细胞发生免疫反应出现转化的指标。这已成为了解免疫治疗效果的必要技术。已报导通过小鼠试验证实霍乱弧菌的神经氨酸酶可从肿瘤细胞表面除去唾液酸基团而提高肿瘤细胞免疫原性,使被其免疫的小鼠对而后超致死剂量肿瘤细胞的攻击有抗性。
In vitro experiments on how to enhance the immunogenicity of tumor cells were explored in patients with tumor cells and solid tumor cells of lymphocytes cultured in order to H ~ 3 - Thymidine incorporation into lymphocytes of the amount of nuclear protein as lymph Cells on the tumor cells immune response occurs indicators of conversion. This has become an essential technique for understanding the effects of immunotherapy. It has been reported that neuraminidase of Vibrio cholerae can be enhanced by mouse experiments to remove sialic acid groups from the surface of tumor cells to enhance the immunogenicity of tumor cells so that the mice immunized with the neuraminidase can then attack the sublethal tumor cells Resistant.