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目的探讨变应性鼻炎患儿血清中白细胞介素25(interleukin-25,IL-25)和白细胞介素12(interleukin-12,IL-12)的表达及与IgE的相关性。方法采用酶联免疫吸附法检测34例变应性鼻炎(allergic rhinitis,AR)患儿和34例健康志愿儿血清中IL-25、IL-12和IgE的含量,并进行比较及相关分析。结果间歇性AR组血清IL-25水平为(42.64.±11.77)ng/L,IL-12水平为(38.52±8.32)ng/L,IgE水平为(563.2±141.7)kU/L;持续性AR组血清IL-25水平为(57.51±5.36)ng/L,IL-12水平为(29.31±11.69)ng/L,IgE水平为(625.6±104.3)kU/L;正常对照组血清IL-25水平为(33.42±9.78)ng/L,IL-12水平为(49.31±11.69)ng/L,IgE水平为(209.7±113.2)kU/L。各组间两两比较,间歇性AR组与持续性AR组、间歇性AR组与对照组、持续性AR组与对照组之间差异均具有统计学意义(P<0.05);AR患儿血清IL-25水平与IL-12水平呈显著负相关(r=-0.453,P<0.01);间歇性AR组与持续性AR组血清IgE水平均与对照组IL-25浓度呈正相关,与IL-12浓度呈负相关,相关系数r分别为0.734和-0.661(P均<0.01)。结论IL-25、IL-12与IgE在AR发病机制中均有重要作用,增强IL-12的活性可为AR治疗提供新的靶点与理论依据。
Objective To investigate the expression of interleukin-25 (IL-25) and interleukin-12 (IL-12) in children with allergic rhinitis and its relationship with IgE. Methods Serum levels of IL-25, IL-12 and IgE in 34 children with allergic rhinitis (AR) and 34 healthy volunteers were detected by enzyme-linked immunosorbent assay and compared and analyzed. Results The levels of serum IL-25 in intermittent AR group were (42.64 ± 11.77) ng / L, IL-12 was (38.52 ± 8.32) ng / L and IgE was 563.2 ± 141.7 kU / The level of IL-25 in serum was (57.51 ± 5.36) ng / L, the level of IL-12 was (29.31 ± 11.69) ng / L and the level of IgE was (625.6 ± 104.3) (33.42 ± 9.78) ng / L, the level of IL-12 was (49.31 ± 11.69) ng / L and the level of IgE was (209.7 ± 113.2) kU / L. The difference between the two groups was statistically significant (P <0.05). There was significant difference between the AR group and the control group (P <0.05) There was a significant negative correlation between IL-25 level and IL-12 level (r = -0.453, P <0.01). Serum IgE level in intermittent AR group and persistent AR group was positively correlated with IL-25 concentration in control group, 12 concentrations were negatively correlated with correlation coefficients r of 0.734 and -0.661, respectively (all P <0.01). Conclusion IL-25, IL-12 and IgE play an important role in the pathogenesis of AR. To enhance the activity of IL-12 may provide a new target and theoretical basis for the treatment of AR.