论文部分内容阅读
目的探讨中国人群中IGF-1和IGFBP-3多态性与前列腺癌易感性的相关性。方法采用以医院为基础的病例对照研究模式,应用Taq Man探针法对IGF-1和IGFBP-3的9个SNPs进行基因分型,检测664例患者和702例对照者的基因型,分层分析与前列腺癌发生有关的可能因素。结果前列腺癌组和对照组进行比较时,rs6218,rs35767和rs5742612的基因型和等位基因频率分布存在显著差异(P=0.005、0.005和0.020)。在综合分析中,具有2~6个风险等位基因的个体患前列腺癌的风险显著高于具有0~1个风险等位基因的个体。研究还发现,组合风险等位基因与前列腺癌风险之间的关联主要表现在以下几组:年龄>71岁(OR=1.41,95%CI=1.05~1.91,P=0.020),不吸烟(OR=1.68,95%CI=1.21~2.32,P=0.002),不喝酒(OR=1.32,95%CI=1.02~1.61,P=0.002),前列腺癌家族史(OR=1.28,95%CI=1.02~1.71,P=0.022)。结论在中国人群中,3个单核苷酸多态性(rs6218,rs35767和rs5742612)和具有2~6个风险等位基因的联合基因型可能与前列腺癌的易感性相关,而与前列腺癌的进展无关。
Objective To investigate the association between IGF-1 and IGFBP-3 polymorphisms and susceptibility to prostate cancer in Chinese population. Methods A hospital-based case-control study was conducted. Genotypes of nine SNPs of IGF-1 and IGFBP-3 were genotyped by TaqMan probe. The genotypes of 664 patients and 702 controls were detected and stratified Analysis of the possible causes of prostate cancer. Results There were significant differences in the genotype and allele frequencies of rs6218, rs35767 and rs5742612 between the prostate cancer group and the control group (P = 0.005, 0.005 and 0.020). In a comprehensive analysis, individuals with 2 to 6 risk alleles had a significantly higher risk of developing prostate cancer than those with 0 to 1 risk alleles. The study also found that the association between the combination of risk alleles and the risk of prostate cancer was mainly manifested in the following groups: age> 71 years (OR = 1.41, 95% CI = 1.05-1.91, P = 0.020) (OR = 1.28, 95% CI = 1.02-1.61, P = 0.002), family history of prostate cancer (OR = 1.28, 95% CI = 1.02 ~ 1.71, P = 0.022). Conclusions In the Chinese population, three SNPs (rs6218, rs35767 and rs5742612) and combined genotypes with 2-6 risk alleles may be associated with prostate cancer susceptibility but not with prostate cancer Progress has nothing to do.