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根据鼠淋巴细胞白血病系统中,培养的白血病骨髓能在根治鼠建立正常造血,推测培养条件促进了正常干细胞的生长,并抑制白血病细胞的发育。新近的研究已提示相似的情况可能应用于人白血病骨髓细胞的培养。本文作者检查了1例有标记染色体的急性粒细胞自血病(AML)病人长期骨髓培养中的造血表现。在培养7到14天后,未见白血病核型细胞。依此发现,在病人明显复发和不能再给蒽环类药治疗时,做了培养骨髓的自身移植。这是应用培养骨髓治疗急性白血病的第一个报告。病人和方法:15岁男孩,患有16q~-核型的 AML,以大剂量柔红霉素(60mg/m~2,3天),阿糖胞苷(200mg/m~2/天,7天)连续输注,和口服硫鸟嘌
According to the murine lymphocytic leukemia system, the cultured leukemia bone marrow can establish normal hematopoiesis in the rooted mice. It is speculated that the culture conditions promote the growth of normal stem cells and inhibit the development of leukemic cells. Recent studies have suggested that similar situations may be applied to the cultivation of human leukemia bone marrow cells. The authors examined the hematopoietic manifestations in a long-term bone marrow culture of a patient with acute granulocytic leukemia (AML) with marker chromosomes. After 7 to 14 days of culture, no leukemia karyotype cells were observed. Based on this finding, self-transplantation of bone marrow was performed when the patient was significantly relapsed and the anthracycline drug could no longer be treated. This is the first report of using cultured bone marrow to treat acute leukemia. PATIENTS AND METHODS: A 15-year-old boy with 16q~-karyotype AML, high-dose daunorubicin (60 mg/m~2, 3 days), cytarabine (200 mg/m~2/day, 7 Days) Continuous infusion, and oral sulphur toxin