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机体免疫功能低下以及肿瘤细胞的抗原性弱是肿瘤与宿主之间的免疫学关系的重要特征。据报道,用免疫调节剂,输入致敏淋巴细胞、转移因子和免疫RNA等进行肿瘤被动免疫治疗,有一定的疗效;此外亦可通过物理(幅射)、化学(导入有抗原性的化学基团)及生物学(酶处理)等方法处理肿瘤细胞,增加其抗原性,而进行主动免疫治疗。 作者将肿瘤细胞与正常细胞人工融合,提高了癌细胞的抗原性。FM3A腹水癌(来自C3H小鼠乳癌)含有一种称为mm抗原的肿瘤相关抗原,其抗原性随染色体数增加而
The low immune function of the body and the weak antigenicity of the tumor cells are important features of the immunological relationship between the tumor and the host. It has been reported that using immunomodulators to import sensitized lymphocytes, transfer factors, and immune RNA for passive immunotherapy of tumors has a certain effect; in addition, it can also be used for physics (radiation) and chemistry (introduction of antigenic chemical groups). Clusters) and biology (enzymatic treatment) methods to treat tumor cells, increase their antigenicity, and active immunotherapy. The authors artificially fuse tumor cells with normal cells to increase the antigenicity of cancer cells. FM3A ascites carcinoma (C3H mouse breast cancer) contains a tumor-associated antigen called mm antigen, whose antigenicity increases with chromosome number.