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血管紧张素转化酶(ACE)抑制剂对严重心衰及高血压有效,但有引起肾功能不全等副作用。本文报道赖诺普利(lisinopril)引起危及生命的代谢紊乱2例。例1,男性,74岁,有重度心衰,经enoximone 100mg 3次/d及赖诺普利20mg/d治疗后有很大改善,但有中度肾损害(血浆肌酐200μmol/L)。
Angiotensin-converting enzyme (ACE) inhibitors are effective in severe heart failure and high blood pressure but cause side effects such as renal insufficiency. This article reports two cases of lisinopril that cause life-threatening metabolic disorders. Example 1 Male, 74 years old with severe heart failure, had a significant improvement after enoximone 100 mg 3 times daily and lisinopril 20 mg daily, but with moderate renal impairment (plasma creatinine 200 μmol / L).