难溶药物的溶出是药物体内吸收的限速步骤，故影响溶出速率的因素一直是人们关心的问题。作者以硫酸钡、奥沙西洋和格列本豚为模型药物，从流体动力学角度研究粒子的大小与形状对表面特定溶出速率的影响。采用库尔特计数技术测定粒子大小，介质采用O．9％NaCI去杂离子溶液，内 Dissolution of insoluble drugs is the rate-limiting step of drug absorption in the body, so the factors that affect the dissolution rate have always been a concern of people. The authors studied the effect of particle size and shape on the specific surface dissolution rate from the perspective of fluid dynamics using barium sulphate, oxsand gibberellin as model drugs. Particle size was measured by Coulter counter technique using O. 9% NaCI de-ionized solution, inside