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为了证实水痘减毒活疫苗的保护效果,作者从缓解期急性淋巴细胞性白血病(ALL)患儿中选择191名水痘易感者作为研究对象。对所有入选儿童于三角肌皮下接种约1,000空斑形成单位(PFU)的水痘减毒活疫苗,以自然感染水痘和进行同样化疗的ALL患儿作对照。对所有受试儿童观察接种反应,并进行免疫学检查:用间接免疫荧光法测定水痘-带状疱疹(VZ)膜抗体;用体外淋巴细胞刺激反应和皮肤试验测定细胞介导免疫。结果表明,接种前,所有受试儿童VZ膜抗体滴度
In order to confirm the protective effect of live attenuated varicella vaccine, the authors selected 191 susceptible individuals of chickenpox from the children with acute lymphoblastic leukemia (ALL) in the remission as the research object. All selected children were vaccinated with an attenuated live attenuated varicella vaccine at about 1,000 plaque-forming units (PFU) in the deltoid muscle to control for naturally infected chickenpox and ALL children who underwent the same chemotherapy. Vaccination was observed in all subjects and immunological tests were performed: Varicella-zoster (VZ) membrane antibodies were measured by indirect immunofluorescence; and cell-mediated immunity was measured by in vitro lymphocyte stimulation and skin tests. The results showed that before inoculation, all tested children had VZ membrane antibody titers