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目的:探讨2型糖尿病对患者颈动脉粥样硬化的影响。方法:90例住院患者分为2型糖尿病组、高血压病组、2型糖尿病并高血压组(混合组)各30例,正常对照组30例。比较各组颈动脉超声检测结果、血脂、血小板活化因子、超敏C反应蛋白、糖化血红蛋白水平。结果:糖尿病组与正常对照组、高血压病组比较软斑指数、三酰甘油明显增多,差异有统计学意义(P<0.05);与正常对照组比较颈动脉内膜-中膜厚度、血小板活化因子、血小板膜上P选择素、总胆固醇、低密度脂蛋白胆固醇、超敏C反应蛋白显著增高,差异均有统计学意义(P<0.01)。结论:2型糖尿病患者血脂、血小板活化因子、超敏C反应蛋白等动脉硬化危险因子水平明显升高,对颈动脉粥样硬化程度有显著影响。
Objective: To investigate the effect of type 2 diabetes on carotid atherosclerosis in patients. Methods: Ninety hospitalized patients were divided into type 2 diabetes mellitus group, hypertension group, type 2 diabetes mellitus and hypertension group (mixed group), 30 cases each, and normal control group, 30 cases. The results of carotid ultrasound examination were compared among groups. The levels of serum lipids, platelet activating factor, high sensitivity C-reactive protein and glycosylated hemoglobin were compared. Results: Compared with the normal control group and the hypertensive group, the diabetic group showed significantly increased plaque index and triglyceride (P <0.05). Compared with the normal control group, carotid artery intima-media thickness, platelet Activation factor, platelet membrane P-selectin, total cholesterol, low density lipoprotein cholesterol, high-sensitivity C-reactive protein were significantly increased, the differences were statistically significant (P <0.01). Conclusion: The levels of atherosclerosis risk factors such as serum lipids, platelet activating factor and high sensitivity C-reactive protein in type 2 diabetic patients are significantly increased, which have a significant effect on the degree of carotid atherosclerosis.