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少年鼻咽血管纤维瘤往往在手术前或放疗前单独用或做为辅助疗法应用雌激素治疗。经在某些肿瘤中所做的临床实验没有能对雌激素出现的客观反应作出解释。因为类固醇激素的作用机制是由特异受体传递的。作者们分析了8例少年的鼻咽血管纤维瘤病例,对其细胞液雌激素受体作了研究。所有患者的雌激素受体均为阴性,且他们的黄体激素受体也都是阴性。其后又对3例患者进行细胞液中有无雄激素受体的检测,结果在肿瘤细胞液里发现有特异睾丸素和与二氢睾酮结合的成分。这一观察首次提示了少年的鼻咽血管纤维瘤可能与雄激素有依赖关系。而雌激素对肿瘤则起到抗雄激素的作用,类似其对于前列腺癌的作用。据估计;少年鼻咽血管纤维瘤占所有头颈部肿瘤的0.05％。作者们测试的8个病例,均为白人,年龄为5～19岁,平均13.5岁。所作组织切片的肿瘤都是典型的鼻咽血管纤维瘤,但未发现雌二醇-17β或睾丸素血清浓度有明显地异
Juvenile nasopharyngeal angiofibroma is often used alone or as an adjunctive therapy for estrogen therapy before surgery or before radiotherapy. Clinical trials performed in certain tumors have not explained the objective response to estrogen. Because the mechanism of action of steroid hormones is transmitted by specific receptors. The authors analyzed the cases of nasopharyngeal angiofibroma in 8 cases of adolescents and studied their cytosolic estrogen receptors. All patients had negative estrogen receptors and all of their progesterone receptors were also negative. Thereafter, 3 patients were tested for the presence of androgen receptors in the cell fluid. As a result, specific testosterone and components that bind to dihydrotestosterone were found in the tumor cell fluid. This observation for the first time suggested that juvenile nasopharyngeal angiofibroma may be associated with androgen dependence. Estrogen, on the other hand, acts as an anti-androgen on tumors, similar to its role in prostate cancer. It is estimated that juvenile nasopharyngeal angiofibroma accounts for 0.05% of all head and neck cancers. The eight cases tested by the authors were white, aged 5-19, with an average age of 13.5 years. The histological sections of the tumors were all typical nasopharyngeal angiofibromas but no significant difference in serum concentrations of estradiol-17β or testosterone was found.