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目的:探讨膀胱小细胞癌病理组织学特点及其诊断与治疗。方法:回顾分析6例膀胱小细胞癌患者的临床和病理资料,6例患者行经尿道膀胱肿瘤电切术2例,膀胱部分切除术1例,行膀胱全切术2例,单纯化疗1例。5例患者接受2～6疗程化疗。结果:6例随访3个月～3年,1例患者术后生存2年至今,5例均因肿瘤转移死亡,平均生存时间14.8个月。结论:膀胱小细胞癌分化程度低、恶性程度高、易早期转移、预后差,主要依靠病理组织学检查确诊,现有治疗方法不足以将其治愈,手术联合化疗是目前主要的治疗方法,分子靶向治疗是未来治疗的主要手段。
Objective: To investigate the histopathological features of bladder small cell carcinoma and its diagnosis and treatment. Methods: The clinical and pathological data of 6 patients with small cell carcinoma of the bladder were retrospectively analyzed. Six patients underwent transurethral resection of the bladder tumor in 2 cases, partial resection of the bladder in 1 case, total cystectomy in 2 cases and chemotherapy alone in 1 case. Five patients received 2 to 6 courses of chemotherapy. Results: Six cases were followed up for 3 months to 3 years. One patient survived 2 years to date and all 5 died of tumor metastasis. The mean survival time was 14.8 months. Conclusions: Small cell carcinoma of bladder has low degree of differentiation, high degree of malignancy, easy early metastasis and poor prognosis. It is mainly diagnosed by histopathological examination, and the existing treatment methods are not enough to cure it. Operation and chemotherapy combined with chemotherapy are the main treatment methods. Molecules Targeted therapy is the main means of future treatment.