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在大鼠条件性饮水反应的建立和巩固过程中,在每天训练之前,通过预先与记录电极一起埋植在海马齿状回的注药管,微量注射去甲肾上腺素(NE),观察其对海马齿状回的习得性长时程突触增强的影响。结果表明:NE能增强突触效应;训练作业前注NE易化了习得性长时程突触增强的形成,但对其巩固无影响;同时相应地易化了动物条件反应的建立。提示NE参与海马齿状回的习得性长时程增强的形成。本文对其可能的作用机制进行了讨论。
During the establishment and consolidation of the conditioned drinking water reaction in rats, norepinephrine (NE) was microinjected by pre-implantation with a recording electrode embedded in the dentate gyrus of the hippocampus prior to daily training to observe the effect of Effect of acquired long-term synaptic enhancement on hippocampal dentate gyrus. The results showed that: NE can enhance the synaptic effect; training before the operation Note NE facilitated the formation of learned long-term synaptic enhancement, but no effect on its consolidation; the corresponding facilitation of the establishment of animal conditioned response. Suggesting that NE participates in the formation of acquired long-term potentiation of the hippocampal dentate gyrus. This article discusses its possible mechanism of action.