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克罗恩病(CD)是一种病因未明确的侵犯胃肠全层的慢性炎症性疾病。病理学上可分为早期、活动期、慢性炎症期或消退期等。临床上相应可分早期、活动期、缓解期或慢性活动期。中国近年发病率有明显增高趋势,推算的发病率与患病率分别为0.848/10万和2.29/10万。肠道黏膜免疫学障碍的研究,很多已得到临床证实与应用。大体病理学特点为节段性(跳跃性)溃疡、卵石征、透壁性炎症和(或)瘘管及肠腔狭窄等;显微镜下可见淋巴细胞浸润,灶性分布,隐窝破坏,裂隙状溃疡及非干酪坏死性肉芽肿等。临床表现为腹痛腹泻,发热与消瘦等。必须依据患者的临床资料综合分析后才能作出诊断。不及时规范治疗,大多数患者需手术治疗,但仍会复发。平均期望寿命略低于正常人。
Crohn’s disease (CD) is a chronic, inflammatory disease that does not specifically affect the entire gastrointestinal tract. Pathology can be divided into early, active, chronic inflammation or regression. The corresponding clinical can be divided into early, active, remission or chronic active phase. In recent years, the incidence rate of China has been significantly increased. The estimated incidence rates and prevalence rates are 0.848 / 100,000 and 2.29 / 100,000 respectively. Intestinal mucosal immunology disorders, many have been clinically confirmed and applied. Gross pathological features of segmental (leaping) ulcers, pebbles sign, transmural inflammation and / or fistula and intestinal stricture, etc .; under the microscope, lymphocyte infiltration, focal distribution, crypt destruction, fissure ulcer And non-cheese necrotic granulomas and so on. Clinical manifestations of abdominal pain, diarrhea, fever and weight loss. Patients must be based on a comprehensive analysis of clinical data to make a diagnosis. Do not regulate treatment in time, most patients require surgical treatment, but will still relapse. Average life expectancy slightly lower than normal.