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药物毒理学是根据药物的理化特性,运用毒理学原理和方法,对药物进行系统的安全性评价并阐明其毒性作用机制,降低药物对机体危害的一门学科,其主要目的在于指导临床合理用药,降低药物不良反应及减少因药物毒性导致的新药开发失败[1]。近年来国内外重大药害事件,尤其是中药不良反应的发生,更加凸显了药物毒理学在药物安全性评价、毒性作用机制研究以及新药早期发现中的重要作用。
Drug toxicology is based on the physical and chemical properties of drugs, the use of toxicological principles and methods of drug safety evaluation system and clarify its toxic mechanism of action to reduce the hazards of drugs on the body of a subject, its main purpose is to guide clinical rational use of drugs , Reduce adverse drug reactions and reduce drug toxicity caused by the failure of new drug development [1]. In recent years, major domestic and international phytosanitary events, especially the occurrence of adverse reactions of traditional Chinese medicine, more highlights the important role of drug toxicology in the evaluation of drug safety, toxic mechanism of action and early detection of new drugs.