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DNA甲基化是一种表观遗传修饰,它与肿瘤的发生关系密切。DNA甲基化是基因表达调控的一种方式。抑癌基因启动子高甲基化可以使其表达失活,导致肿瘤发生。胃癌的发生与多基因异常表达密切相关,其中抑癌基因甲基化是胃癌发生发展的重要机制之一。
DNA methylation is an epigenetic modification that is closely related to the occurrence of tumors. DNA methylation is a way of regulating gene expression. Hypermethylation of the tumor suppressor gene promoter inactivates its expression, leading to tumorigenesis. The occurrence of gastric cancer is closely related to the abnormal expression of multi-gene. Methylation of tumor suppressor gene is one of the important mechanisms of gastric cancer.