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Carbon monoxide is thought to serve as a new endogenous mediator in the pathogenesis of sepsis andseptic shock. In newborn rat endotoxicosis, carbon monoxide levels in the circulation as well as liver, kid-ney and lung were found to be significantly increased (P<0. 05). Moreover, the elevations of carbonmonoxide correlated with enhanced nitric oxide production as indicated by nitrite/nitrate levels (P<0. 05).Our present data showed for the first time that endogenously produced carbon monoxide was increasedduring the course of shock-like states, which suggested that the role of carbon monoxide in sepsis and sep-tic shock might worth further study.
Carbon monoxide is thought to serve as a new endogenous mediator in the pathogenesis of sepsis and septic shock. In newborn rat endotoxicosis, carbon monoxide levels in the circulation as well as liver, kid-ney and lung were found to be significantly increased (P <0 05). Moreover, the elevations of carbonmonoxide correlated with enhanced nitric oxide production as indicated by nitrite / nitrate levels (P <0. 05). Our present data showed for the first time that endogenously produced carbon monoxide was increased the course of shock -like states, which suggested that the role of carbon monoxide in sepsis and sep-tic shock might worth further study.