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本文报告了人参茎叶皂(以下简称CS)可增加正常大鼠肾上腺细胞内cAMP的含量,且与ACTH有协同作用。去垂体的大鼠则无此作用说明GS的拟ACTH样作用是通过垂体,而非直接作用于肾上腺皮质。同时观察了人参茎叶二醇组皂甙、三醇组皂及人参单体皂R_(b2)、R_e、R_g、R_d对肾上腺细胞内cAMP含量的动态变化,以二醇组皂及单体Rd作用最显著,故二醇组皂和单体皂Rd可能是兴奋垂体的主要皂。本实验比较了GS和人参皂对垂体的兴奋作用,两者作用强度基本相同,故在此方面GS可代替人参皂。这为人参的综合利用提供一定的实验依据。
This article reports that Ginseng Stem and Leaf Soap (hereinafter referred to as CS) can increase the content of cAMP in the adrenal glands of normal rats, and has a synergistic effect with ACTH. Pituitary rats do not have this effect, suggesting that the quasi-ACTH-like action of GS is through the pituitary gland, rather than acting directly on the adrenal cortex. At the same time, the dynamic changes of cAMP content in adrenal cells were observed with ginseng stem-leaf glycol group saponin, triol group soap and ginseng monomer soap R_(b2), R_e, R_g, and R_d. The effect of diol group soap and monomer Rd was observed. The most significant, so diol group soap and monomer soap Rd may be the main soap excited pituitary. This experiment compared the excitatory effects of GS and ginsenosides on the pituitary gland. The strength of the two is basically the same. Therefore, GS can replace ginseng soap in this respect. This provides a certain experimental basis for the comprehensive utilization of ginseng.