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目的 :观察丹酚酸A(SA A)抗肝细胞过氧化损伤时在抑制肝星状细胞 (HSC)增殖中的作用。方法 :以不同浓度的丙二醛 (MDA)刺激HSC ,通过氚标胸腺嘧啶 (3H[TdR])掺入法 ,观察对HSC增殖作用 ,以及SA A对损伤肝细胞MDA含量及促HSC增殖的影响。结果 :一定浓度的MDA有促进HSC增殖的作用 ;损伤肝细胞MDA含量明显增加 ;SA A可抑制损伤肝细胞对HSC的促增殖作用 ,并可降低损伤肝细胞MDA的含量。结论 :SA A可通过抗肝细胞过氧化损伤抑制HSC的增殖。
Objective: To observe the effect of salvianolic acid A (SA A) on inhibiting the proliferation of hepatic stellate cells (HSC) induced by peroxidation of hepatocytes. Methods: The HSCs were stimulated with different concentrations of malondialdehyde (MDA), and the proliferation of HSC was observed by 3H-TdR incorporation. The effect of SA A on the MDA content and the proliferation of HSC influences. Results: A certain concentration of MDA could promote the proliferation of HSC. The content of MDA in injured hepatocytes increased significantly. SA A could inhibit the proliferation of hepatic cells and the content of MDA in injured hepatocytes. Conclusion: SA A can inhibit the proliferation of HSC through anti-hepatocyte peroxidation injury.