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目的探讨二甲双胍对2型糖尿病合并原发性亚临床甲状腺功能减退患者血清促甲状腺激素(TSH)水平的影响。方法选取2013年6月至2015年5月大连大学附属中山医院收治的125例2型糖尿病合并原发性亚临床甲状腺功能减退患者作为研究对象,按随机数字表法将其分为观察组(63例)和对照组(62例)。观察组患者采用二甲双胍进行治疗,对照组患者口服左旋甲状腺素钠片,比较两组患者治疗前后的空腹血糖(FBG)值、餐后2 h血糖(2 h PBG)及血清TSH水平。结果治疗后,观察组患者的FBG、2 h PBG均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患者的血清TSH水平为(1.3±0.8)m IU/L,明显低于对照组的(1.8±1.7)m IU/L,差异有统计学意义(t=7.1042,P<0.05)。结论二甲双胍可有效改善2型糖尿病合并原发性亚临床甲状腺功能减退患者血清TSH水平,降低血糖值,是2型糖尿病合并原发性亚临床甲状腺功能减退患者的理想治疗药物。
Objective To investigate the effect of metformin on serum thyroid stimulating hormone (TSH) levels in type 2 diabetic patients with primary subclinical hypothyroidism. Methods A total of 125 patients with type 2 diabetes mellitus complicated with primary subclinical hypothyroidism who were admitted to Zhongshan Hospital Affiliated to Dalian University from June 2013 to May 2015 were selected as study subjects and divided into observation group (63 Cases) and control group (62 cases). Patients in the observation group were treated with metformin. Patients in the control group were given oral levothyroxine sodium tablets. The fasting blood glucose (FBG), postprandial blood glucose (2 h PBG) and serum TSH levels were compared between the two groups before and after treatment. Results After treatment, FBG and 2-h PBG in the observation group were significantly lower than those in the control group (all P <0.05). After treatment, the serum TSH level in the observation group was (1.3 ± 0.8) m IU / L was significantly lower than that of the control group (1.8 ± 1.7) m IU / L, the difference was statistically significant (t = 7.1042, P <0.05). Conclusion Metformin can effectively improve the level of serum TSH in patients with type 2 diabetes mellitus complicated with primary subclinical hypothyroidism and lower the blood glucose level. It is an ideal treatment for type 2 diabetes mellitus patients with primary subclinical hypothyroidism.