采用ＭＴＴ比色法检测了青年妇女、围绝经妇女及绝经后妇女的血清ＩＬ６活性、血清Ｅ２水平及Ｌ２－４骨密度（ＢＭＤ）值。结果：绝经后妇女血清ＩＬ６活性明显升高，ＢＭＤ值显著低于青年妇女与围绝经妇女（Ｐ＜００１），血清Ｅ２水平也显著低于青年妇女与围绝经妇女（Ｐ＜００１）。相关分析显示：ＩＬ６与ＢＭＤ呈负相关（Ｐ＜００５），与Ｅ２呈负相关（Ｐ＜００１）；Ｅ２与ＢＭＤ呈正相关（ｒ＝０６６０，Ｐ＜００１）。结果表明，Ｅ２缺乏及其所致的ＩＬ６活性升高与绝经后妇女的骨丢失有关，可能参与了绝经后骨质疏松的发病机理。 MTT colorimetric method was used to detect serum IL6 activity, serum E2 level and L2-4 BMD in young women, perimenopausal women and postmenopausal women. Results: Serum IL6 activity in postmenopausal women was significantly higher than that in young women and perimenopausal women (P <001), serum E2 levels were significantly lower than those in young women and perimenopausal women (P <001) 01). Correlation analysis showed that IL6 was negatively correlated with BMD (P <005) and negatively correlated with E2 (P <001), E2 was positively correlated with BMD (r = 0660, P <001 ). The results show that the lack of E2 and the resulting increase in IL 6 activity associated with bone loss in postmenopausal women may be involved in the pathogenesis of postmenopausal osteoporosis.