目的　探讨托吡酯治疗小于 6个月婴儿癫疗效和安全性。方法　小于 6个月癫 35例 ,均口服托吡酯 1～ 2 .4mg/ (kg·d) ,每隔 3～ 4天增加 1～ 2 .4mg/ (kg·d) ,直至控制发作或不能耐受为止 ,最大剂量 15mg/ (kg·d)。进行自身开放对照研究。结果　 4周有效率 91.4 % ,其中完全控制 5 1.4 %。随访 5～ 32个月 ,平均用量 5 .6mg/ (kg·d) ,完全控制 5 7.1% ,有效 88.5 %。结论　托吡酯治疗小婴儿癫安全有效 ,副作用少。 Objective To investigate the efficacy and safety of topiramate in the treatment of epilepsy in infants less than 6 months old. Methods 35 cases of epilepsy less than 6 months were given topiramate 1 ~ 2.4mg / (kg · d), every 3-4 days increased 1-2.4mg / (kg · d), until the control of attack or intolerance Subject, the maximum dose of 15mg / (kg · d). Conduct their own open-label study. The results of 4 weeks 91.4% efficiency, of which full control of 51.4%. The patients were followed up for 5 to 32 months with an average dosage of 5.6 mg / (kg · d), with complete control of 51.1% and effective rate of 88.5%. Conclusion Topiramate treatment of epilepsy in infants is safe and effective, with few side effects.