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目的 比较不同胰岛素给药方式对糖尿病酮症酸中毒(DKA)的治疗差异。方法 将DKA患者随机分为胰岛素治疗组(CSⅡ)和常规治疗组(对照组) ,观察治疗后血糖、尿酮体的变化及低血糖的发生率。结果 两组患者的血糖经治疗后达标时间差异有显著意义(P <0 . 0 1) ;尿酮体转阴时间较对照组明显缩短,差异有显著意义(P <0 . 0 1) ;CSⅡ组低血糖发生率较对照组明显减少,差异有显著意义(P <0. 0 5 )。结论 胰岛素泵持续皮下输注胰岛素治疗DKA较常规小剂量静脉注射胰岛素更安全、有效。
Objective To compare the therapeutic effects of different insulin dosage forms on diabetic ketoacidosis (DKA). Methods Patients with DKA were randomly divided into insulin treatment group (CS Ⅱ) and conventional treatment group (control group). The changes of blood glucose and urine ketone body and the incidence of hypoglycemia were observed after treatment. Results The blood glucose levels of the two groups were significantly different after treatment (P0.01), and the duration of urine ketone bodies was significantly shorter than that of the control group (P0.01) The incidence of blood glucose was significantly lower than the control group, the difference was significant (P <0. 05). Conclusion Insulin pump sustained subcutaneous infusion of insulin treatment of DKA than conventional low-dose intravenous insulin safer and more effective.