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自1983年以来,已有几所院校妇产科遗传实验室,用羊水微绒毛膜酶法产前诊断囊性纤维性变(CF),最重要的酶有肽酶如谷氨酰转移酶(GGT),双糖酶如海藻糖酶和磷酸酶如碱性磷酸酶(ALP)等。由于受累器官(汗腺、胰、肠、支气管)腺细胞富有微绒毛,故CF胎儿微绒毛膜酶活性低于一般水平。作者五年来对54例高风险CF妊娠及125例正常妊娠的羊水标本检查了绒毛膜酶,并用判定分析法分析了生化诊断的敏感性、特异性和可信性。将上述179例妊娠作了以下8项处理:孕妇羊水穿刺时的年龄、遗传咨询、孕妇血清AFP值、超声所见、羊水蛋白
Since 1983, several gynecological and gynecological genetic laboratories have been used to diagnose cystic fibrosis (CF) prenantially with amniotic fluid microenvironmental enzyme. The most important enzymes are peptidases such as glutamyl transferase (GGT), disaccharidases such as trehalase and phosphatase such as alkaline phosphatase (ALP) and the like. As the affected organs (sweat gland, pancreas, intestine, bronchus) glandular cells rich in microvilli, CF fetal microvilli enzyme activity below the normal level. In the past five years, the authors examined chorioamnion in 54 high-risk CF pregnancies and 125 normal-pregnancy amniotic fluid samples and analyzed the sensitivity, specificity, and credibility of biochemical diagnostics using diagnostic tests. The 179 cases of pregnancy made the following eight treatment: pregnant women amniocentesis age, genetic counseling, serum AFP values of pregnant women, ultrasound findings, amniotic protein