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Large conductance calcium-activated potassium(BKCa)channels are broadly expressed in vascular smooth muscle cells(VSMCs)and play a crucial role in the regulation of vascular tone[1].Activation of BKCachannel by elevation of the[Ca~(2+)]idue to membrane depolarization increases the K~+ conductance of the membrane,and drives the VSMC membrane potential to hyperpolarization,which in
Large conductance calcium-activated potassium (BKCa) channels are broadly expressed in vascular smooth muscle cells (VSMCs) and play a crucial role in the regulation of vascular tone [1]. Activation of BKCachannel by elevation of the [Ca ~ (2+) ] idue to membrane depolarization increases the K ~ + conductance of the membrane, and drives the VSMC membrane potential to hyperpolarization, which in