过去25年中,不仅药物分子方面取得了巨大进展,而且组成药物制剂的材料(如赋形剂)也取得了很大的进展。本文的目的就是对这些进展加以综述并就它们的应用情况(尤其是用于片剂和胶囊的情况)作一评价。以25年为一周期之所以是合适的,是因为1960年代表这一时期中近似的转折点,即那一年直接压片技术第一次正式用于工业化生产。 Not only has tremendous progress been made in drug molecules over the past 25 years, but material making up pharmaceutical preparations such as excipients has also made great strides. The purpose of this article is to review these advances and make an assessment of their application, especially in the case of tablets and capsules. The 25-year cycle is appropriate because the 1960 represents the approximate turning point in this period, when direct compression was officially put into commercial production for the first time in that year.