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运用核仁蛋白组成区嗜银蛋白染色术检测了５例正常胎盘，１例合体细胞子宫内膜炎，２２例葡萄胎，１０例恶性葡萄胎，２例胎盘部位中间型滋养细胞肿瘤和１９例绒癌，发现恶性滋养细胞肿瘤的ＡｇＮＯＲ／核均数明显高于良性滋养细胞肿瘤（Ｐ＜０．００１），细胞滋养细胞中的ＡｇＮＯＲ／核均数亦明显高于合体滋养细胞（Ｐ＜０．００１）。同时发现良恶性滋养细胞肿瘤的ＡｇＮＯＲ颗粒分布类型也不同，良性病变以弥漫型为主，而恶性病变以颗粒型为主，表明主要用于细胞遗传学的ＡｇＮＯＲ技术在肿瘤病理学上有广泛的应用价值。
Five cases of normal placenta, one case of syncytial endometritis, 22 cases of hydatidiform mole, 10 cases of malignant mole, 2 cases of placental intermediate trophoblastic tumor and 19 cases were examined using nucleolar protein composition argentin staining. In choriocarcinoma, the AgNOR/nucleus average of malignant trophoblastic tumors was significantly higher than that of benign trophoblastic tumors (P<0.001), and the AgNOR/nucleus average number in cytotrophoblasts was also significantly higher than that of syncytiotrophoblasts (P<0). .001). At the same time, the AgNOR particle distribution patterns of benign and malignant trophoblastic tumors are also different. The benign lesions are mainly diffuse and the malignant lesions are mainly granular. This indicates that the AgNOR technology mainly used for cytogenetics has extensive tumor pathology. Value.