AIM:Preoperative intra-arterial infusion chemotherapycould increase the radical resection rate of advanced gastriccancer,but its effect on the long-term survival has notbeen assessed.This study was designed to evaluate theclinical significance of preoperative intra-arterial infusionchemotherapy for advanced gastric cancer.METHODS:Clinicopathological data of 91 patients whounderwent curative resection for advanced gastric cancerwere collected.Among them,37 patients undertakenpreoperative intra-arterial infusion chemotherapy were usedas the interventional chemotherapy group,and the remaining54 patients as the control group.Eleven factors includingclinicopathological variables,treatment procedures andmolecular biological makers that might contribute to thelong-term survival rate were analyzed using Cox multivariateregression analysis.RESULTS:The 5-year survival rate was 52.5% and 39.8%,respectively,for the interventional group and the controlgroup(P<0.05).Cox multivariate regression analysisrevealed that the TNM stage(P<0.001),preoperative intra-arterial infusion chemotherapy(P=0.029)and growthpattern(P=0.042)were the independent factors for thelong-term survival of patients with advanced gastric cancer.CONCLUSION:Preoperative intra-arterial infusion chemotherapyplays an important role in improving the prognosis of advancedgastric cancer. AIM: Preoperative intra-arterial infusion chemotherapycould increase the radical resection rate of advanced gastriccancer, but its effect on the long-term survival has not been evaluated. This study was designed to evaluate the clinical significance of preoperative intra-arterial infusion chemotherapy for advanced gastric cancer. METHODS : Clinicopathological data of 91 patients whounderwent curative resection for advanced gastric cancer tissue collected. Among them, 37 patients previously generated intra-arterial infusion chemotherapy were used as the interventional chemotherapy group, and the remaining 54 patients as the control group. Eleven factors including clinical pathology variables, treatment procedures andmolecular biological makers that might contribute to the long-term survival rate were analyzed using Cox multivariate regression analysis .RESULTS: The 5-year survival rate was 52.5% and 39.8%, respectively, for the interventional group and the controlgroup (P <0.05) .Cox multivariate regression analy Preoperative intra-arterial infusion chemotherapy (P = 0.029) and growth pattern (P = 0.042) were the independent factors for the long-term survival of patients with advanced gastric cancer. CONCLUSION: Preoperative intra- arterial infusion chemotherapyplays an important role in improving the prognosis of advanced gastric cancer.