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目的通过检测PI3Kp85在鼻咽癌组织及鼻咽部慢性炎症组织中的表达情况,探讨它们在鼻咽癌发生、发展过程中的作用。方法采用免疫组织化学SP法检测PI3Kp85在57例鼻咽癌和20例鼻咽部黏膜慢性炎症组织中的表达情况,应用Image-ProPlus图像分析软件测定免疫组化图像的平均光密度(mean optical density,MOD),运用SPSS13.0软件进行统计学分析,观察其与鼻咽癌临床病理特征之间的关系。结果PI3Kp85在鼻咽癌组织的阳性表达率为78.95%,而在鼻咽部慢性炎症组织中的阳性表达率为45.00%,两者差异有统计学意义(P<0.05)。PI3Kp85表达与临床分期、淋巴结转移、原发病灶大小及患者年龄、性别均无相关性(P>0.05)。结论PI3Kp85蛋白表达可能与鼻咽癌的发生有关。
Objective To detect the expression of PI3Kp85 in nasopharyngeal carcinoma tissues and nasopharyngeal chronic inflammatory tissues and to explore its role in the occurrence and development of nasopharyngeal carcinoma. Methods Immunohistochemical SP method was used to detect the expression of PI3Kp85 in 57 cases of nasopharyngeal carcinoma and 20 cases of chronic inflammation of nasopharyngeal mucosa. The average optical density (IOD) of immunohistochemistry was measured by Image-ProPlus image analysis software. , MOD), using SPSS 13.0 software for statistical analysis, and observe the relationship between the clinicopathological features of nasopharyngeal carcinoma. Results The positive expression rate of PI3Kp85 in nasopharyngeal carcinoma was 78.95%, while it was 45.00% in chronic nasopharyngeal tissues, the difference was statistically significant (P <0.05). There was no correlation between PI3Kp85 expression and clinical stage, lymph node metastasis, size of primary lesion and age and gender of patients (P> 0.05). Conclusion PI3Kp85 protein expression may be related to the occurrence of nasopharyngeal carcinoma.