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苯妥英钠的抗癫痫作用虽然尚不够理想,但到目前为止,仍为癫癎大发作及局灶性发作等的首选药物之一。近年来对苯妥英钠的血浓度测定的应用,进一步加深了对其药物动力学及临床应用方面的了解。一、药物动力学中的一些特点:1.吸收:本药口服时,其生物利用度约为90％。达峰时间为3～10小时。应用一般剂量时,血浓度要6～10天才能达到有效水平。肌肉注射刺激性大,且可能在肌肉中形成结晶,因其吸收速度较口服还慢而不规则,故难以保证有效的血药浓度,因此不宜采用肌肉注射。必需特别指出的是血药浓度的升高与口服剂量增加不成比例,在日用量500毫克范围内,日用量每增加100毫
Although phenytoin sodium antiepileptic effect is not yet ideal, but so far, is still the epileptic seizures and focal seizures and other drug of choice. In recent years, the application of the determination of the blood concentration of phenytoin sodium has further deepened the understanding of its pharmacokinetics and clinical application. First, some of the characteristics of pharmacokinetics: 1. Absorption: The oral administration of this drug, its bioavailability of about 90%. Peak time is 3 to 10 hours. Application of the general dose, the blood concentration to 6 to 10 days in order to achieve effective levels. Muscle injection irritation, and may form a crystal in the muscle, because of its absorption rate is slower than the oral and irregular, it is difficult to ensure effective blood concentration, it is not appropriate to use intramuscular injection. It must be particularly pointed out that the increase in blood concentration and oral dose increase disproportionate, in the daily dose of 500 mg, the daily dose for each additional 100 milliliters