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目的 观察外周静脉血中性粒细胞和单核细胞膜CD11b/CD18表达在急性冠状动脉综合征 (ACS)患者中的变化 ,探讨其与斑块稳定性的关系。方法 选 30例ACS患者 (ACS组 )、2 4例稳定型心绞痛患者 (SA组 ) ,30例冠状动脉造影阴性作对照组。流式细胞仪直接免疫荧光法检测CD11b/CD18的表达。结果 中性粒细胞和单核细胞膜CD11b/CD18的表达ACS组显著高于SA组(P <0 0 1)和对照组 (P <0 0 1)。结论 ACS患者中性粒细胞和单核细胞膜CD11b/CD18的表达增加与斑块不稳定性有关
Objective To observe the changes of CD11b / CD18 expression on peripheral blood venous blood neutrophil and monocyte membrane in patients with acute coronary syndrome (ACS) and to explore its relationship with plaque stability. Methods Thirty ACS patients (ACS group), 24 patients with stable angina pectoris (SA group) and 30 patients with coronary angiography were selected as control group. Flow cytometry direct immunofluorescence assay CD11b / CD18 expression. Results The expression of CD11b / CD18 on neutrophil and monocyte membrane in ACS group was significantly higher than that in SA group (P <0.01) and control group (P <0.01). Conclusions The increased expression of CD11b / CD18 on neutrophil and monocyte membrane in ACS patients is related to plaque instability