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[目的]探讨乙肝疫苗母婴阻断无(弱)应答发生的影响因素。[方法]选择北京市顺义区2005~2008年孕期或住院分娩时乙肝病毒表面抗原(HBsAg)检测阳性母亲所生的儿童,分析乙肝疫苗母婴阻断无(弱)应答发生的影响因素,在单因素的基础上进行多因素非条件Logistic回归分析,探索接种乙肝疫苗阻断HBV母婴传播的影响因素。[结果]共调查223名儿童,抗-HBs阳性者185人,阳性率为85.7%,无(弱)应答率为14.3%。非条件Logistic回归分析结果显示,HepB首针及时接种、儿童完成接种年龄、分娩方式及母亲HBV感染状况是影响儿童抗-HBs无弱应答率的主要因素,其发生无(弱)应答的OR值分别为0.264、2.292、2.158和0.370。[结论]乙肝疫苗接种后的无(弱)应答率与文献报道基本一致。HepB首针未及时接种、儿童完成接种年龄较大、顺产及母亲双阳性的儿童乙肝疫苗母婴阻断时容易发生无(弱)应答。
[Objective] To investigate the influencing factors of no (weak) response in blocking hepatitis B vaccine in maternal and infant. [Methods] The children born in HBsAg-positive mothers during the period of pregnancy from 2005 to 2008 in Shunyi District, Beijing, or during hospital delivery were analyzed. The influencing factors of no (weak) Based on the single factor, multivariate non-conditional Logistic regression analysis was conducted to explore the influencing factors of hepatitis B vaccine blocking HBV transmission. [Results] Totally 223 children were enrolled and 185 were positive for anti-HBs. The positive rate was 85.7% and no (weak) response rate was 14.3%. The results of non-conditional Logistic regression analysis showed that the first inoculation of HepB, the completion of vaccination, the mode of delivery and the status of HBV infection in mothers were the main factors influencing the non-responder rate of anti-HBs in children. The OR value of no (weak) response Respectively 0.264, 2.222, 2.158 and 0.370. [Conclusion] No (weak) response rate after hepatitis B vaccination was basically consistent with that reported in the literature. HepB first needle was not timely vaccination, children completed vaccination of older, spontaneous and mothers double positive children hepatitis B vaccine prone to block (weak) response.