非何杰金氏恶性淋巴瘤,早在1956年Rappaport 根据瘤细胞形态、大小和组织结构,提出分类,1966年正式分类命名。近来随着免疫学发展,以免疫、组化、电镜等新技术研究证实,淋巴瘤本质是以肿瘤性形态表现的免疫性疾病,并被 Lukes-Collins 首先在1975年阐述免疫功能分类,是淋巴瘤发 Non-Hodgkin’s lymphoma, as early as 1956 Rappaport classification based on tumor cell morphology, size and structure, classification officially named in 1966. Recently with the development of immunology, immunization, histochemistry, electron microscopy and other new technologies confirmed that the nature of lymphomas is an autoimmune disease manifested in a neoplastic form and was first described by Lukes-Collins in 1975 as an immunological classification of lymphoid Tumor