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目的探讨辽宁地区汉族人群中FoxO1基因rs 17446614单核苷酸多态性与2型糖尿病(type 2diabetes mellitus,T2DM)的相关性。方法选取到中国医科大学附属第四医院进行体检的健康人(正常对照)366名及T2DM患者395例,采用分子量阵列技术(MassARRAY)检测FoxO1基因rs 17446614单核苷酸多态性,探讨其与T2DM的相关性。结果糖尿病组与正常对照组rs 17446614基因型均以GG纯合子为多见,分别为78.48%和84.15%,AA纯合子为少见基因型,分别为1.52%和0.27%,两组间比较,差异有统计学意义(P<0.05)。等位基因频率均以G为多见;A等位基因为少见基因型,糖尿病组和正常对照组分别为11.52%和8.06%,两组间差异有统计学意义(P<0.05)。结论辽宁地区汉族人群FoxO1基因rs 17446614中AA基因型及A等位基因可能是T2DM的易感基因。
Objective To investigate the association between FoxO1 rs17446614 SNP and type 2 diabetes mellitus (T2DM) in Han population of Liaoning Province. Methods A total of 366 healthy controls (normal controls) and 395 T2DM patients were selected from the Fourth Affiliated Hospital of China Medical University. The single nucleotide polymorphisms of rs17446614 in FoxO1 gene were detected by molecular mass array technique (MassARRAY) T2DM correlation. Results The genotypes of rs17446614 in diabetic group and normal control group were all more common with GG homozygotes, which were 78.48% and 84.15% respectively. AA homozygotes were rare genotypes, which were 1.52% and 0.27% respectively. There was significant difference between the two groups There was statistical significance (P <0.05). Allele frequencies were more common in G; A allele was a rare genotype, diabetes and normal control group were 11.52% and 8.06%, the difference between the two groups was statistically significant (P <0.05). Conclusion AA genotype and A allele of rs17446614 in FoxO1 gene of Liaoning Han population may be susceptible genes of T2DM.