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目的 :探讨中药复方脑脉Ⅱ号对急性脑缺血性损伤的保护作用及其机制。方法 :采用电子显微镜观察及放射性核素示踪法等技术 ,从结构与功能方面进行研究。结果 :脑脉Ⅱ号能减轻急性脑缺血大鼠大脑皮层组织结构的损伤程度 ;提高缺血脑组织SOD、GSH -PX活性 ,并减少LPO含量 ;能增加脑组织3H -脱氧葡萄糖含量。结论 :脑脉Ⅱ号能减轻缺血对脑细胞的损伤 ,从而起保护作用 ,其作用机制可能与对抗自由基攻击和减少能量消耗等有关。
Objective: To investigate the protective effect and mechanism of Chinese herbal medicine compound Naomai II on acute cerebral ischemic injury. Methods : Electron microscopy and radionuclide tracer techniques were used to study the structure and function. RESULTS: Naomai II could reduce the damage degree of cerebral cortex tissue in rats with acute cerebral ischemia, increase the activity of SOD and GSH-PX in ischemic brain tissue, decrease the content of LPO, and increase the content of 3H-deoxyglucose in brain tissue. Conclusion : Naomai II can reduce the damage of ischemic brain cells, and thus play a protective role. The mechanism may be related to fighting free radicals and reducing energy consumption.