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目的探讨衡阳地区HIV感染者和AIDS患者T淋巴细胞亚群的免疫病理改变情况及其临床意义。方法收集59例HIV感染者(HIV组)、50例AIDS患者(AIDS组)、31例健康体检人员(正常对照组)的抗凝血,用流式细胞仪单平台技术检测外周血T4及T8淋巴细胞。结果正常对照组、HIV组、AIDS组外周血T4细胞计数分别为(673±362,337±278)、(129±124)(个/μl),组间比较,正常对照组明显高于HIV组和AIDS组(P<0.01);T8细胞计数分别为(478±243)、(940±844)、(707±636)(个/μl),HIV组明显高于对照组(P<0.05);T4细胞与T8细胞比值(TH/S)分别为(1.49±0.90)、(0.39±0.38)、(0.18±0.17),正常对照组明显高于HIV组和AIDS组(P<0.05)。结论综合分析T淋巴细胞不同亚群的改变,能反映HIV感染者和AIDS患者的免疫受损情况和疾病的严重程度。
Objective To investigate the immunopathological changes of T lymphocyte subsets in HIV-infected and AIDS patients in Hengyang and its clinical significance. Methods Anticancer blood was collected from 59 HIV-infected patients (HIV group), 50 AIDS patients (AIDS group) and 31 healthy controls (normal control group). Flow cytometry was used to detect peripheral blood T4 and T8 Lymphocytes. Results The counts of T4 cells in peripheral blood of normal control group, HIV group and AIDS group were (673 ± 362,337 ± 278) and (129 ± 124) (a / μl) respectively. Compared with HIV group and AIDS group, (P <0.01). The counts of T8 cells were (478 ± 243), (940 ± 844) and (707 ± 636), respectively, significantly higher in HIV group than in control group (P <0.05) (1.49 ± 0.90), (0.39 ± 0.38) and (0.18 ± 0.17), respectively, compared with HIV / AIDS group (P <0.05). Conclusion The comprehensive analysis of the changes of different subsets of T lymphocytes can reflect the immune damage and the severity of the disease in HIV-infected and AIDS-infected patients.